Monday 11/11- Veterans Day- no school
Tuesday 11/12- /Wednesday 11/13
TED Talk Craig Venter- the first artificial cell:
Project Summary:
Scientists have built a bacterial genome from scratch and used it to 'reboot' a cell from a different species of bacterium. Daniel Gibson and his colleagues at the J. Craig Venter Institute in Rockville, Maryland, synthesized the genome of the bacterium Mycoplasma mycoides, consisting of about 1.1 million base pairs. Having assembled the genome inside a yeast cell, they transplanted it into a cell from a closely related species, Mycoplasma capricolum. After the newly made cell had divided, the cells of the bacterial colony that it formed contained only proteins characteristic of M. mycoides.
The success clears the way for developing and testing new variants of existing organisms.
"With this approach we now have the ability to start with a DNA sequence and design organisms exactly like we want," says Gibson. "We can get down to the very nucleotide level and make any changes we want to a genome."
Published online 20 May 2010 | Nature | doi:10.1038/news.2010.253
Quick write:
Besides having the capability of reproducing itself, what cellular functions would be needed to be part of the design criteria for the cell as well?
Artificial cell design concept (Q/E/SP-5 points)
Design criteria:
You and your cytoengineering team are designing a synthetic cell. This synthetic cell should be able to carry out specific biological functions (i.e. movement, compartmentalization, waste recycling/intracellular digestion, protein synthesis, packaging of proteins, intracellular transport, mechanical/structural support, energy transfer, and protection (from internal or external threats) to help ensure its survival. Draw a 2D cross-section of your cell on poster board (or digitally constructed model) and label the structures that carry out these critical functions.
*When hearing about the proposed design of other cyto engineering teams provide constructive feedback for how to improve their design or concerns you might have about their design.
Thursday
- Artificial cell design challenge- work day
Friday/Monday (November 18)
-Unit 8 FRQ- go over
Artificial cell design work day- Be ready to present next Tuesday/Wednesday BOP
Tuesday 11/12- /Wednesday 11/13
- The inner workings of a cell- animation-
- Score Chapter 4 Review/Chapter 5 Review due Thursday, November 21
- Cliffs- Chapters 2 and 3 due Thursday BOP (M/C only)
- Macro organic molecules - progress check- Assigned in AP Classroom- due BOP
TED Talk Craig Venter- the first artificial cell:
Project Summary:
Scientists have built a bacterial genome from scratch and used it to 'reboot' a cell from a different species of bacterium. Daniel Gibson and his colleagues at the J. Craig Venter Institute in Rockville, Maryland, synthesized the genome of the bacterium Mycoplasma mycoides, consisting of about 1.1 million base pairs. Having assembled the genome inside a yeast cell, they transplanted it into a cell from a closely related species, Mycoplasma capricolum. After the newly made cell had divided, the cells of the bacterial colony that it formed contained only proteins characteristic of M. mycoides.
The success clears the way for developing and testing new variants of existing organisms.
"With this approach we now have the ability to start with a DNA sequence and design organisms exactly like we want," says Gibson. "We can get down to the very nucleotide level and make any changes we want to a genome."
Published online 20 May 2010 | Nature | doi:10.1038/news.2010.253
Quick write:
Besides having the capability of reproducing itself, what cellular functions would be needed to be part of the design criteria for the cell as well?
Artificial cell design concept (Q/E/SP-5 points)
Design criteria:
You and your cytoengineering team are designing a synthetic cell. This synthetic cell should be able to carry out specific biological functions (i.e. movement, compartmentalization, waste recycling/intracellular digestion, protein synthesis, packaging of proteins, intracellular transport, mechanical/structural support, energy transfer, and protection (from internal or external threats) to help ensure its survival. Draw a 2D cross-section of your cell on poster board (or digitally constructed model) and label the structures that carry out these critical functions.
- your cell design must be for a single-celled, eukaryotic-like organism that is BC (biologically correct)
- You may select the environment that your cell lives in, and the types and combinations of organic molecules found in that environment. These organic molecules must serve as the raw materials from which the structures composing your cell arise, and from which the cell derives energy and structure.
- For your design explain some of the limitations for your artificial cell- (e.g. scale, physical, chemical, etc.) and why those limitations apply to your design.
- Be creative!
- Present your design to the class- Tuesday/Wednesday Nov. 19/20
- explain to your classmates how the structures in your synthetic cell design would carry out each of the functions (identified above) necessary for its survival in its selected environment.
- explain how a malfunction or failure of at least two different structures would affect the vitality of the organism (stating that it would die is not a sufficient response).
- describe some of the limitations for your artificial cell- scale, physical, chemical limitation
- Each person should contribute equally to the development of your cell design and its explanation and will be evaluated by their group members for their contribution to this project.
*When hearing about the proposed design of other cyto engineering teams provide constructive feedback for how to improve their design or concerns you might have about their design.
Thursday
- Artificial cell design challenge- work day
Friday/Monday (November 18)
-Unit 8 FRQ- go over
Artificial cell design work day- Be ready to present next Tuesday/Wednesday BOP